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Karolinska Development’s portfolio company Promimic AB announces that its HAnano Surface improves implant-to-bone integration for PEEK implants

GÖTEBORG 2016-04-08 – Promimic AB today announced the results of an in vivo proof of concept study on Polyether ether ketone (PEEK) implants coated with nano-sized hydroxyapatite published in International Journal of Nanomedicine.

The results of the study show a significant improvement of bone-to-implant contact for the Hydroxyapatit (HA) nano coated implants compared to uncoated controls at 3 weeks and 12 weeks follow-up. In addition, a perforating hole in the implant showed significantly more bone area for the HA-coated implants at both healing points.

“We are tremendously satisfied with the results. The results does not only show that our surface material significantly improves the osteogenic properties of PEEK implants. It also shows a level of improvement that is clinically relevant and may help overcome the shortcomings of PEEK as a bioinert material with poor bone forming properties. Translating these results to the clinical situation, meaning it does not necessarily have to be a trade-off any more between the mechanical properties of the material and its ability for osseointegration.” comments Ulf Brogren, CEO of Promimic AB.

The article:

Polyether ether ketone implants achieve increased bone fusion when coated with nano-sized hydroxyapatite: a histomorphometric study in rabbit bone

Authors: Pär Johansson, Ryo Jimbo, Yoshihito Naito, Per Kjellin, Fredrik Currie, Ann Wennerberg

The study was conducted in a collaboration between the Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden; Oral Implant Center, Tokushima University Hospital, Tokushima, Japan and Promimic AB.

THE PEEK MATERIAL

To overcome the problems of inferior outcomes of titanium and cobalt-chrome alloys PEEK was introduced to the orthopedic field as an implant material due to its similar elastic properties as that of human bone. For the past 2 decades, PEEK has become a common alternative to metal implants in several orthopedic applications. However, PEEK has shown both in in vivo and in vitro studies to have low bioactive features due to the relatively bioinert surface. Therefore, a lot of effort has been made to improve the biocompatible state of PEEK by incorporating bioactive substances into the substrate or onto the surface as a coating.

THE HAnano SURFACE

This new surface represents a new era of implant surfaces, based on bio-mimicking synthetic bone minerals. The unique HAnano Surface is only 20 nanometers thin and is proven to improve and accelerate osseointegration in over 20 pre-clinical studies. Through its wet chemical process it can be applied to almost any implant material and shape improving the integration with bone. This is the third published in vivo study showing that the HAnano Surface improves the integration between bone and PEEK implants. The HAnano Surface is already in clinical use on dental implants in Brazil.


ABOUT PROMIMIC AB

Promimic, based in Gothenburg, Sweden, develops and markets products within nano-materials for innovative surface treatments. Promimic has developed a process that makes it possible to modify all types of implant materials and geometries with a nanometer-thin surface of synthetic bone minerals; HAnano Surface. The HAnano Surface is based on the substance hydroxyapatite (HA), which by size, shape, structure and chemistry mimics the living bone tissue. The surface has been shown to fasten and improve the anchoring of implants in bone. The innovative HAnano Surface is licensed to dental and orthopaedic implants companies. For more information about the company, please visit the web page: http://www.promimic.com.

Contact
Tel: +46 730 79 42 07 Email:
ulf@promimic.com

 News release as PDF

2016-04-08